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14D2I10 - Experimental methods in pharmacology and toxicology

Course specification
Course title Experimental methods in pharmacology and toxicology
Acronym 14D2I10
Study programme DOCTORAL ACADEMIC STUDIES
Module
Type of study PhD academic studies
Lecturer (for classes)
Lecturer/Associate (for practice)
    Lecturer/Associate (for OTC)
      ESPB 10.0 Status elective
      Condition Enrolled fourth semester Oblik uslovljenosti
      The goal To learn the basic methods and techniques in experimental pharmacology and toxicology. In order to know the way of selection of adequate research methods and its proper application. To learn specific statistical methods of processing the results obtained in pharmacological and toxicological research.
      The outcome As a result of this course students must learn all of the most important methods of experimental pharmacological and toxicological investigations and that the results obtained in the study knows to analyze by the appropriate statistical methods.
      Contents
      Contents of lectures General Part: Calculations in Pharmacology and Toxicology; Solutions: molar concentration, percentage concentration, dose determination and dose calculation; Methods for testing the dose (concentration) and effect of the drug (toxin). Methods of pharmacological testing in anesthetized and non-anesthetized animals; Test methods on isolated organs. Caenorhabditis elegans as an experimental model. Equipment for testing on isolated organs, measuring isometric and isotonic contractions. Special Part Experimental Pharmacology: Trials of CNS-acting Drugs. Trials of drugs acting on the peripheral nervous system. Analgesic test methods. Cardiovascular drug testing methods. Respiratory drug test methods. Investigations of the effects of drugs acting on the gastrointestinal tract. Tests for uterine-acting drugs. Testing of drugs that affect the urinary system. Tests for parasite-acting drugs. Pharmacokinetic experimental models. Special part Experimental toxicology: Acute toxicity test methods, subacute toxicity, chronic toxicity; Inhalation toxicity test methods; Dermal toxicity testing methods; Ocular toxicity testing methods; Dermal irritation test methods; Reproductive toxicity testing methods; Test methods for teratogenicity and genotoxicity; Carcinogenicity testing methods.
      Contents of exercises Work in the pharmacodynamic laboratory of the Department of Pharmacology and Toxicology
      Literature
      1. Varagić M.V., Milošević P.M. (2010) Farmakologija, Elit Medica, Beograd. (Original title)
      2. PHARMACOLOGICAL EXPERIMENTS ON ISOLATED PREPARATIONS. By the Staff of the Department of Pharmacology, University of Edinburgh. Edinburgh and London: E. & S. Livingstone. 1968. (Original title)
      Number of hours per week during the semester/trimester/year
      Lectures Exercises OTC Study and Research Other classes
      4
      Methods of teaching Lectures, seminar papers, consultations.
      Knowledge score (maximum points 100)
      Pre obligations Points Final exam Points
      Activites during lectures 10 Test paper
      Practical lessons Oral examination 70
      Projects
      Colloquia
      Seminars 20