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14D2I28 - Drugs action mechanisms

Course specification
Course title Drugs action mechanisms
Acronym 14D2I28
Study programme DOCTORAL ACADEMIC STUDIES
Module
Type of study PhD academic studies
Lecturer (for classes)
Lecturer/Associate (for practice)
    Lecturer/Associate (for OTC)
      ESPB 10.0 Status elective
      Condition Enrolled semester in which the subject is attended. Oblik uslovljenosti
      The goal Well-known mechanisms of action of the drugs of all pharmacodynamic groups used in veterinary medicine. Make clear and understandable differences in the mechanisms of the therapeutic and side effects of drugs, as well as differences in the mechanisms that exert a antagonisitic or synergistic drug interactions.
      The outcome As a result of the course, the student must know the basic principles of the mechanisms by which drugs of different pharmacodynamic groups act. Student should understand the mechanisms of action of drugs and use this knowledge in further scientific work with drugs.
      Contents
      Contents of lectures General Part: Introduction to Pharmacodynamics, Subject and Task; Drugs, origin, nature; Introduction of new drugs - preclinical and clinical trials of drugs; Pharmacodynamics, effect of drugs on the organism, types and character of action, place and mechanisms of action of drugs; Receptors, drug-receptor interaction, receptors and transmembrane signal transduction, consequences of receptor drug binding (receptor internalization, agonist-antagonist system), receptor desensitization, receptor regulation; Ion channels as drug sites of action, sodium, calcium, potassium, chloride channels; Enzymes as drug sites; Transport cell systems as a site of action of drugs; Quantitative aspects of drug action: dose-effect ratio, gradual and quantum; Pharmacodynamic models and pharmacodynamic parameters; Tolerance, tachyphylaxis and resistance mechanisms and types; Dosage and dosing of drugs, types of doses, expression of doses; Drug interactions: synergism and antagonism; Drug selectivity, side effects, adverse reactions of genetic origin and pharmacogenetics, allergic reactions; Drug addiction, mechanisms of formation and types of addiction. Special part: Mechanisms of action of drugs acting on different organ systems.
      Contents of exercises Experimental work in the pharmacodynamic laboratory at the Department of Pharmacology and Toxicology.
      Literature
      1. 1. Rang H., Maureen M.D., Ritter J.M., Moore P.K. (2006) Farmakologija, Data status prevod sa Engleskog, urednik Prof. dr Zoran Todorović. (Original title)
      2. 2. Varagić M.V., Milošević P.M. (2010) Farmakologija, Elit Medica, Beograd. (Original title)
      Number of hours per week during the semester/trimester/year
      Lectures Exercises OTC Study and Research Other classes
      4
      Methods of teaching Lecturing; preparation of seminar and public presentation of the experimetal work.
      Knowledge score (maximum points 100)
      Pre obligations Points Final exam Points
      Activites during lectures 10 Test paper 70
      Practical lessons Oral examination
      Projects
      Colloquia
      Seminars 20