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14D1O01 - Molecular biology of a cell

Course specification
Course title Molecular biology of a cell
Acronym 14D1O01
Study programme DOCTORAL ACADEMIC STUDIES
Module
Type of study PhD academic studies
Lecturer (for classes)
Lecturer/Associate (for practice)
    Lecturer/Associate (for OTC)
      ESPB 10.0 Status obligatory
      Condition Oblik uslovljenosti
      The goal Acquainting students with the principles and mechanisms of functioning cells at the molecular level; to gain knowledge in the field of cell biology necessary for research in modern biomedicine
      The outcome To provide students with knowledge relating to: - the structure and function of cells at the molecular level - the interaction between organelles and transport mechanisms within the cell - communication mechanisms between cells of eukaryotic organisms - the molecular basis of development and cell differentiation –molecular basis of carcinogenesis - the methods and techniques of molecular biology cell
      Contents
      Contents of lectures Origin and functional organization of procaryotic and eucaryotic cells (cell compartments and topological relationships, methods for separation and purification of cells and organelles); Cell membrane (structure and function of membrane components; transport through the membrane); The nucleus (sheath and lamina; pore complex, transport through the pores; nucleolus and maturing subunits of the ribosome); Structure and properties of genetic material (properties of molecules and DNA organization, replication, repair and recombination of DNA prokaryotes and eukaryotes; the expression of genetic information, control of gene expression; basic genetic engineering); Structure, synthesis, sorting and transport proteins in the cell (endoplasmic reticulum, Golgi system); Interaction between organelles and vesicular transport; Mitochondria (structure and function, gene, protein transport into mitochondria); The cytoskeleton and cell initiation; Communication between cells (signaling molecules, receptors, signal transduction systems); Control of the cell cycle, aging and cell death; The molecular basis of development and differentiation, control mechanisms of cellular differentiation during early embryogenesis; epigenetic mechanisms controlling gene expression); The molecular basis of carcinogenesis.
      Contents of exercises
      Literature
      1. Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P.: Molecular Biology of the Cell, 6th ed., Garland Science, Taylor & Francis Group, New York, 2015 (Original title)
      2. Berg et al, Biochemistry, 5th ed, Freeman & Co, 2002 (Original title)
      3. Mihailović M, Jovanović M.: Biohemija, 5 izdanje, Naučna KMD, Beograd, 2008 (Original title)
      4. Gledić D.: Veterinarska histologija, Veterinarska komora Srbije, Beograd 2012 (Original title)
      5. Ross M.H., Pawlina W.: Histology: A Text And Atlas With Correlated Cell and Molecular Biology,6th ed., Wolters Kluwer, Lippincott, Williams & Wilkins, Baltimore, Philadelphia, 2011 (Original title)
      6. Lodish H, Berk A, Zipursky SL, Matsudaira P, Baltimore D, Darnell J, Molecular Cell Biology, 4th ed, WH Freeman Co, New York, 2000 (Original title)
      7. Cooper GM, The Cell - A Molecular Approach, ASM Press, Washington DC, 1997 (Original title)
      Number of hours per week during the semester/trimester/year
      Lectures Exercises OTC Study and Research Other classes
      4
      Methods of teaching Lectures, seminar,
      Knowledge score (maximum points 100)
      Pre obligations Points Final exam Points
      Activites during lectures 10 Test paper 70
      Practical lessons Oral examination
      Projects
      Colloquia
      Seminars 20