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20I1O02 - Medicinal chemistry

Course specification
Course title Medicinal chemistry
Acronym 20I1O02
Study programme Veterinary Medicine
Module
Type of study Integrated academic studies
Lecturer (for classes)
Lecturer/Associate (for practice)
Lecturer/Associate (for OTC)
    ESPB 4.0 Status obligatory
    Condition Enrolled semester in which the course is taken Oblik uslovljenosti
    The goal Acquiring knowledge and understanding of structures and properties of simple and complex molecules, getting to know chemical reactions of organic and inorganic compounds that are crucial for the processes in cells of the organism, as well as the chemical laws and mechanisms that underlie these processes. Laboratory exercises provide basic laboratory techniques as well as the ability to use laboratory procedures.
    The outcome After completing this course, the student should: - recognizes and understands the structure of basic and complex molecules, as well as chemical laws that are crucial for the chemical and biochemical reactions in the body - acquires the ability to integrate theoretical knowledge and practical skills in laboratory practice - compare and connect the structures and properties of organic compounds and biomolecules - possesses practical skills of independent and team work in theoretical presentation as well as in laboratory analyzes - masters and independently uses methods of analytical chemistry, qualitative and quantitative analysis - gains safety in laboratory work - solves chemistry tasks independently by calculation
    Contents
    Contents of lectures Intra- and intermolecular bonds. Covalent and noncovalent interactions in biomacromolecules. Thermodynamic changes of chemical reactions in living systems. Water, aqueous solutions, structure biomolecules as a consequence of interaction with water. Chemical equilibria in aqueous solutions. Mechanism of buffer action and capacity. Structure of organic molecules. Hydroxyl and thiol derivatives of hydrocarbons. Carbonyl derivatives of hydrocarbons. Carboxylic acids and biologically important substituted acids. Amines. Carboxylic acid derivatives. Carbohydrates- stereochemistry, reactivity. Simple and complex lipids. Structure and properties of amino acids, peptides and proteins. Coenzymes.
    Contents of exercises Qualitative chemical analysis. Solutions, buffers, indicators and pH. Quantitative chemical analysis. Analysis of organic compounds. Qualitative analysis of carbohydrates and lipids.
    Literature
    1. Borozan S: Odabrana poglavlja iz Medicinske hemije, Naučna KMD, Beograd, 2012.
    2. Borozan S, Krstić M, Đorđević I: Praktikum iz Medicinske hemije sa radnom sveskom i zbirkom zadataka za studente I godine, Fakulteta veterinarske medicine Univerziteta u Beogradu, Naučna KMD, Beograd, 2010.
    Number of hours per week during the semester/trimester/year
    Lectures Exercises OTC Study and Research Other classes
    2 1
    Methods of teaching Theoretical teaching with interactive learning, with the application of audio-visual methods (PowerPoint presentation). Practical exercises are performed individually in the experimental laboratory.
    Knowledge score (maximum points 100)
    Pre obligations Points Final exam Points
    Activites during lectures 3 Test paper 45
    Practical lessons 10 Oral examination
    Projects
    Colloquia 38
    Seminars 4